SERVICES
 
 

Capabilities

 
  Expertise  
  Clients  
     

Expertise

 

MAJOR THERAPEUTIC AREAS

  • ONCOLOGY
    Cellular and clinical oncology; hematologic and gynecologic malignancies; solid tumors; non-small cell lung cancer;  prostate, breast, endometrial, and colon cancer; head and neck cancer; tumor microenvironment; novel cancer therapies; telomerase inhibitors and activators; stromal-epithelial interactions and cell signaling; organotypic models of tumor development; animal models of cancer, including human tumor xenografts, syngeneic models, and genetically engineered (transgenic) models.
  • BIOLOGICS & BIOTECHNOLOGY
    TNF-alpha inhibitors; monoclonal antibodies; PEGylated and liposomal drug delivery; recombinant therapeutic proteins and vaccines; candidates for vaccine development; novel therapeutics; 3-D tissue reconstruction, biomatrices for cellular and tissue engineering; cytoskeleton-based therapeutics; biophotonics and microscopy in drug discovery; role of genomics, proteomics in translational and individualized medicine.
  • RESPIRATORY & ALLERGIC DISEASE
    Asthma; allergy, including seasonal allergic rhinitis; H1/H2 receptor antagonists; inhaled corticosteroids, corticosteroid pills; bronchodilators; leukotriene receptor agonists and theophylline; chronic obstructive pulmonary disease (COPD).
  • CHRONIC INFLAMMATION AND AUTOIMMUNITY
    Rheumatoid arthritis; psoriatic arthritis; psoriasis; osteoarthritis; Crohn's disease; ankylosing spondylitis; atopic dermatitis; Sjogren's syndrome.
  • STEM CELLS
    Theory, cell culture technology, and emerging therapeutic applications; adult vs. embryonic vs. umbilical cord-derived stem cell origins; the cancer stem cell hypothesis and its controversy; novel imaging approaches to monitor stem cell differentiation and/or integration into tissue.
  • INFECTIOUS DISEASE & ANTI-INFECTIVES
    Opportunistic infections in immunocompromised patients; lipid-based delivery systems for antifungal therapy; tuberculosis;hepatitis;HIV-1 mutagenesis; anti-viral therapies; nucleoside and non-nucleoside reverse transcriptase inhibitors; anthrax; avian influenza A H5N1;cytomegalovirus (CMV).
  • TRANSPLANTATION
    Bone marrow transplantation, stem cell transplantation, solid organ transplantation; immunocompromised hosts; xenotransplantation; implantation or infusion of cells and tissue.
  • SKELETAL MAINTENANCE
    Bone health and bone remodeling; effects of chemotherapy on bone health; tumor-induced osteolysis; bisphosphonates; RANK signaling pathway inhibitors as therapeutic strategy to prevent bone degradation; osteoporosis
  • WOMEN'S HEALTH
    Physiology and treatment issues of endometriosis; heart, bone, and reproductive health; menopause; human steroid hormone receptors (estrogen, progesterone); mechanisms of human infertility; assisted reproductive technologies such as IVF; human embryo implantation, fetal development and birth defects.
  • CARDIOVASCULAR
    Genetic links of endothelial inflammation to coronary artery disease and vascular disease; angiogenesis; inflammation as a key pathogenetic mechanism in atherosclerosis; endothelial cell phenotypes in heart, lung, and blood disease; endothelial function in response to ischemia; inflammatory markers for cardiovascular disease (selectins, cytokines, acute-phase reactants).